Epidemiology Pathogenesis And Prevention Of Head And Neck Cancer Pdf

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Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer

Selected lifestyle characteristics of incident cases of head and neck squamous cell carcinoma HNSCC and matched controls. JAMA Oncol. The main risk factors for HNC are increasing age, male sex, cigarette smoking, and alcohol consumption. Two meta-analyses of case-control studies 8 , 16 showed strong associations of HPV detection at the time of diagnosis with tonsillar cancer odds ratios [OR], Follow-up questionnaires were sent every 2 years to CPS-II-NC participants and annually to PLCO cohort members to update information on lifestyle exposures and health status, and to ascertain newly diagnosed cancers.

We designed parallel nested case-control studies among participants who provided informed consent, baseline questionnaire data, and a mouthwash sample in each cohort. The definition of HNSCC included cancers of the following sites: oral cavity excluding salivary glands , tongue, oropharynx including tonsils and base of the tongue , hypopharynx, and larynx.

A detailed description of inclusion criteria for each cohort is provided in eMethods in the Supplement. The present study was reviewed and deemed exempt by the institutional review board of Albert Einstein College of Medicine. The original cohort studies received full institutional review board approval from both the American Cancer Society and the National Cancer Institute, and written informed consent was obtained from all study participants for the original data collection.

All HPV testing was performed at the Albert Einstein College of Medicine, and all laboratory personnel were blinded to the case-control status of the mouthwash samples. Total DNA was purified from exfoliated oral cavity epithelial cells obtained from a mouthwash rinse specimen, as described previously. We considered a sample to be positive for HPV if it scored positive in 2 of 3 assays. For the few participants with missing information on pack-years of smoking 3 cases and 9 controls from both cohorts or alcoholic drinks per week 22 cases and 46 controls from both cohorts , their missing data were imputed as described in eMethods in the Supplement.

We also tested for interactions between covariates in conditional logistic regression models, but there were no statistically significant interactions. All statistical models were adjusted for the same variables as the models investigating the overall risk of incident HNSCC.

Participant demographic and lifestyle characteristics of incident cases of HNSCC and their matched controls are listed in Table 1. Cases were more likely than controls to be current smokers and alcohol drinkers. However, there were no major differences with regard to body mass index, education, or marital status between the 2 groups see eTable 1 in Supplement. Our results show that HPV detection in the oral cavity, which preceded cancer diagnosis for an average of 3. This association is consistent with results of prior case-control studies of oral HPV and prevalent HNC, 8 , 16 , 29 - 33 although such studies do not provide evidence for a temporal relationship.

In a hospital-based case-control study cases, controls in Iowa City, Smith and colleagues 29 reported ORs of 2. Only 1 study has shown that anti-E6 antibodies for HPV detected in prospectively collected serum samples is positively associated with HNSCC incidence, in particular oropharyngeal cancer.

The lack of data on this issue is due, in part, to the relative rarity of these cancers, requiring large sample sizes for longitudinal prospective data and collection of mouthwash samples. We used the collection of oral mouthwash samples originally intended to isolate genomic DNA in 2 large prospective cohort studies with verified cancer end points to efficiently determine whether HPV detection in the oral cavity precedes cancer development. These papillomaviruses are anticipated to play a role in the initiation of the tumorigenic process since neither the viral genomes nor transcripts are detected in skin cancers.

Such a study is complicated for the skin, given the high prevalence of HPV in the skin and hair follicles 37 - 39 and the difficulty of sampling a specific anatomic site that will in the future develop skin cancer.

Nevertheless, HPV vaccines to prevent skin cancer are under consideration. This study has strengths and limitations. Limitations of this study include the limited sample size of cases, reflecting the rarity of HNSCC and its anatomic subtypes. Published Online: January 21, Author Contributions: Drs Agalliu and Burk had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Conflict of Interest Disclosures: None reported. The American Cancer Society supports the follow-up and maintenance of the Cancer Prevention Studies, which contributed data to this project. In addition, there was a separate DCP contract for a data management and analysis center. Our website uses cookies to enhance your experience.

Table 1. View Large Download. Table 2. Table 3. Selected lifestyle characteristics of incident cases of head and neck squamous cell carcinoma HNSCC and matched controls eTable 2.

Providing clinicians and patients with actual prognosis: cancer in the context of competing causes of death. J Natl Cancer Inst Monogr. PubMed Google Scholar Crossref. Cancer statistics, CA Cancer J Clin. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

J Natl Cancer Inst. Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver. Eur J Cancer Prev. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States.

J Clin Oncol. Epidemiology of human papillomavirus-related head and neck cancer. Otolaryngol Clin North Am. Global burden of human papillomavirus-positive head and neck cancers. Lancet Oncol. Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin Otolaryngol. Epidemiology of HPV in head and neck cancer, human papillomavirus and related diseases.

Rijeka, Croatia: InTech; Role of human papillomavirus in the etiology of head and neck cancer. Head Neck. HPV and head and neck cancers: state-of-the-science. Oral Oncol. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. Lack of association of alcohol and tobacco with HPVassociated head and neck cancer. Epidemiology and clinical aspects of HPV in head and neck cancers.

Head Neck Pathol. Human papillomavirus and cancerous diseases of the head and neck: a systematic review and meta-analysis. Oral Dis. Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions. Int J Epidemiol. Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. High-risk HPV types and head and neck cancer.

Int J Cancer. The oral cavity contains abundant known and novel human papillomaviruses from the Betapapillomavirus and Gammapapillomavirus genera.

J Infect Dis. Methods for etiologic and early marker investigations in the PLCO trial. Mutat Res. J Med Virol. PLoS One. Regression analysis of matched case-control data. Am J Epidemiol. PubMed Google Scholar. Modern Epidemiology. Lyon, France: Accessed December 14, Human papillomavirus in oral exfoliated cells and risk of head and neck cancer. Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada.

Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. Demographic and risk factors in patients with head and neck tumors.

Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. Oral human papillomavirus in healthy individuals: a systematic review of the literature. Sex Transm Dis. Case-control study of genus-beta human papillomaviruses in plucked eyebrow hairs and cutaneous squamous cell carcinoma.

Human papillomavirus load in eyebrow hair follicles and risk of cutaneous squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev.

Epidemiological Trends in Head and Neck Cancer and Aids in Diagnosis

BBSB, Rm. Head and neck cancers represent the sixth most common cancer worldwide with approximately , new patients diagnosed annually resulting in more than , deaths every year 1. In high-risk countries i. In the United States U. By contrast, there is a recent upsurge in the incidence of oropharyngeal squamous cell carcinoma OPSCC which is attributed to a change in the biologic driver of SCC in this region with an increasing frequency of an association with high-risk subtypes of human papilloma virus HPV 4 , 5.

Head and neck cancers HNCs are specifically defined as cancers of the upper aerodigestive tract, which includes the oral cavity, the mucosal lip, the oropharynx, the hypopharynx, the nasopharynx, the larynx, and the salivary glands. Alcohol consumption. Heavier consumption of alcohol is associated with increased HNC risk. There is also a possibility of genetic susceptibility to HNC among certain heavy drinkers of alcohol that may predispose them to such cancers. HPV infection. Individuals with HPV-positive HNCs tend to be younger, healthier fewer comorbid diseases than in long-term tobacco and alcohol users , and have different behavior- related risk factors, including more sexual partners and earlier ages of onset of sexual activity. Currently there are more than viral types of HPV.


Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer PDF · Descriptive Epidemiology: U.S. Patterns. Linda Morris Brown, Gloria Gridley, Susan S. Devesa Occupation and Other Risk Factors for Head and Neck Cancer.


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Metrics details. Infection with human papillomavirus HPV is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic review and meta-analysis of the prevalence of HPV infection in head and neck cancers, focusing on data for European populations. MEDLINE, Embase and grey literature sources were systematically searched for primary studies that were published in English between July and July , and which reported on the prevalence of HPV infection in head and neck cancers in European populations.

Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?

Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer provides a current perspective on the epidemiology of head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established associations with tobacco and alcohol use, the human papilloma virus, and potential determinants of genetic susceptibility. Because of these factors, head and neck cancer offers a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction. This book brings together the latest epidemiologic and molecular genetic evidence regarding the patterns of occurrence and causes of head and neck cancer. In addition, Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer considers approaches to chemoprevention, and incorporates a multidisciplinary perspective including salient clinical, pathologic, molecular, and epidemiologic contributions.

Selected lifestyle characteristics of incident cases of head and neck squamous cell carcinoma HNSCC and matched controls. JAMA Oncol. The main risk factors for HNC are increasing age, male sex, cigarette smoking, and alcohol consumption. Two meta-analyses of case-control studies 8 , 16 showed strong associations of HPV detection at the time of diagnosis with tonsillar cancer odds ratios [OR], Follow-up questionnaires were sent every 2 years to CPS-II-NC participants and annually to PLCO cohort members to update information on lifestyle exposures and health status, and to ascertain newly diagnosed cancers. We designed parallel nested case-control studies among participants who provided informed consent, baseline questionnaire data, and a mouthwash sample in each cohort. The definition of HNSCC included cancers of the following sites: oral cavity excluding salivary glands , tongue, oropharynx including tonsils and base of the tongue , hypopharynx, and larynx.

It seems that you're in Germany. We have a dedicated site for Germany. Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer provides a current perspective on the epidemiology of head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established associations with tobacco and alcohol use, the human papilloma virus, and potential determinants of genetic susceptibility. Because of these factors, head and neck cancer offers a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction. This book brings together the latest epidemiologic and molecular genetic evidence regarding the patterns of occurrence and causes of head and neck cancer. In addition, Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer considers approaches to chemoprevention, and incorporates a multidisciplinary perspective including salient clinical, pathologic, molecular, and epidemiologic contributions.

Oral complications of radiotherapy in the head and neck. Radiotherapy is a treatment modality largely used for head and neck malignancies. However, high doses of radiation in large areas, including the oral cavity, maxilla, mandible and salivary glands may result in several undesired reactions. AIM: The aim of this study is to briefly review the side effects that may be seen in the oral cavity during or after radiotherapy treatment in the head and neck region. Keywords: Radiotherapy.

Chemoprevention of HNSCC is a means of cancer control with a use of drugs or natural agents in order to hinder or delay the cancer development. In case of HNSCC there is currently no agent, which would give positive result in the third phase of clinical trials. Promising results of preclinical trials are not always confirmed by further tests. Main problems are low effectiveness, high toxicity, and lack of highly specificity biomarkers for monitoring the research.

Но Стратмор смотрел на молодого сотрудника лаборатории систем безопасности.

 О мой Бог! - воскликнула Сьюзан.  - Дэвид, ты просто гений. ГЛАВА 121 - Семь минут! - оповестил техник. - Восемь рядов по восемь! - возбужденно воскликнула Сьюзан.

Человек улыбнулся: охота становилась интересной. Беккер здесь… Я чувствую, что. Он двигался методично, обходя один ряд за другим.

 Это многое объясняет, - настаивала .

Мы просто исполнили его последнюю волю. Беккер смягчился. В конце концов, Росио права, он сам, наверное, поступил бы точно так .

Но вот туфли - совсем другое. Даже во время учебы в колледже она старалась покупать самую лучшую обувь. Нельзя дотянуться до звезд, если чувствуешь себя ущемленной, - сказала как-то ее тетушка.  - И если уж попала туда, куда стремилась, постарайся выглядеть на все сто.

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  1. Guerin R.

    Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer DRM-​free; Included format: PDF; ebooks can be used on all reading devices.

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