Causes Of Cleft Lip And Palate Pdf

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Cleft lip or palate is one of the most common types of craniomaxillofacial birth anomalies. Midface deficiency is a common feature of cleft lip and palate patients due to scar tissue of the lip and palate closure. Cleft lip and palate patients should be carefully evaluated by the craniofacial team in order to detect potentially serious deformities.

Click here to view a larger image. The lip forms between the fourth and seventh weeks of pregnancy. As a baby develops during pregnancy, body tissue and special cells from each side of the head grow toward the center of the face and join together to make the face.

Cleft Lip and Palate Patients: Diagnosis and Treatment

A cleft lip is an opening or split in the upper lip that occurs when developing facial structures in an unborn baby don't close completely. Cleft lip may be unilateral or bilateral. A baby with a cleft lip may also experience a cleft in the roof of the mouth cleft palate. A cleft palate is an opening or split in the roof of the mouth that occurs when the tissue doesn't fuse together during development in the womb. A cleft palate often includes a split cleft in the upper lip cleft lip but can occur without affecting the lip.

Cleft Lip and Palate

Clefts may affect one side unilateral or both sides bilateral of the lip. In nearly all cases, clefts of the lip affect the tip of the nose as well. Cleft lip and cleft palate can occur together or separately. A variety of factors can increase the risk of a baby being born with a cleft lip or palate. Prenatal exposure to alcohol, cigarettes, and other medications and drugs increases the risk, but in most instances, there is no single explanation. Instead, a combination of many factors is the usual cause. In some cases, clefts occur as part of a genetic syndrome that often includes other birth defects.


What causes cleft lip and cleft palate? For most babies with cleft lip and/or cleft palate, the reason for the improper fusion is not known. Some families.


Epidemiology, Etiology, and Treatment of Isolated Cleft Palate

A clinical examination followed by necessary diagnostic work-up was completed for each case. Environmental causes were found in 6 children four mothers developed hyperthermia during the 2 nd month of gestation, one mother was diabetic, and one mother was a known case of epilepsy and took sodium valproate throughout her pregnancy. Six children were suffering from known genetic malformation syndromes each with Jarcho-Levin syndrome, Oral-Facial-Digital syndrome type XI, Oral-Duplication syndrome, Kabuki syndrome, Fronto-nasal dysplasia and Nager syndrome. Novel chromosomal aberrations were identified in 2 children. These findings were compared with regional and international studies.

Last Updated September This article was created by familydoctor. The word cleft means split or break. Cleft lip is an opening in the upper lip and nose.

Related Conditions & Syndromes

Isolated cleft palate CPO is the rarest form of oral clefting. The incidence of CPO varies substantially by geography from 1. Approximately fifty percent of cases born with cleft palate occur as part of a known genetic syndrome or with another malformation e.

This means the cleft itself is caused by the condition or syndrome. When figuring out how likely a person with one of these is to pass on their cleft, you have to look at how likely they are to pass on the condition or syndrome first. Having a cleft alone does not mean that an individual has one of these conditions. Most of these syndromes and conditions affect people to different degrees. Some people do not even realise they have issues other than their cleft. Other rare syndromes, such as Edwards Syndrome or Patau Syndrome, are much more serious, but these are routinely tested for during pregnancy.

They occur in approximately one in births. This causes a gap or defect to occur in the affected area, involving skin, muscle and the lining of the mouth. There is often an associated deformity of the nose on the affected side. Similarly, a cleft palate may occur in isolation, without a corresponding deformity of the upper lip. Various family and environmental factors may contribute to a child's cleft.


A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit.


Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth.

5 Response
  1. Isaac S.

    Risk factors. Family history. Parents with a family history of cleft lip or cleft palate face a higher risk of having a baby with a cleft. Exposure to certain substances during pregnancy. Having diabetes. Being obese during pregnancy.

  2. Michelle M.

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  3. Charles V.

    Cleft lip and cleft palate are thought to be caused by a combination of genes and other factors, such as things the mother comes in contact with in her environment, or what the mother eats or drinks, or certain medications she uses during pregnancy.

  4. Leonard M.

    In most cases, the cause of cleft lip and cleft palate is unknown. These conditions cannot be prevented. Most scientists believe clefts are due to.

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